Sequence-specific Ni(II)-dependent peptide bond hydrolysis for protein engineering: Active sequence optimization
نویسندگان
چکیده
منابع مشابه
Sequence-specific Ni(II)-dependent peptide bond hydrolysis in a peptide containing threonine and histidine residues.
Previously we demonstrated that Ni(II) complexes of Ac-Thr-Glu-Ser-His-His-Lys-NH2 hexapeptide, representing residues 120-125 of human histone H2A, and some of its analogs undergo E-S peptide bond hydrolysis. In this work we demonstrate a similar coordination and reactivity pattern in Ni(II) complexes of Ac-Thr-Glu-Thr-His-His-Lys-NH2, its threonine analogue, studied using potentiometry, electr...
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ژورنال
عنوان ژورنال: Journal of Inorganic Biochemistry
سال: 2013
ISSN: 0162-0134
DOI: 10.1016/j.jinorgbio.2013.07.037